Tolerance Induction in Kidney Transplantation
نویسندگان
چکیده
منابع مشابه
Chimerism and tolerance induction in kidney transplantation.
Chimerism is a state in which bone marrow hematopoietic stem cells from two genetically different animals coexist. To date, the approach has been used successfully to induce the state of immunologic tolerance in the animal models and is now being evaluated in clinical trials of both HLA-identical and HLA-mismatched living-donor kidney transplant recipients in some transplant centers with varyin...
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Advances in immunosuppressive treatments led us to better control acute rejection and improve graft survival in organ transplantation. However, immunosuppressive drugs, due to their toxicity, are also responsible for many side effects as opportunistic infections, renal failure, cardiovascular disease and malignancy (Stegall et al, 1997; Soulillou et al, 2001; Ojo et al, 2003; Fishman et al, 200...
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Kidney transplantation in patients with end stage renal disease is preferred to dialysis because transplantation provides a better quality of life andimproved survival. However, the gap between the supply and demand for a renal allograft is widening and the waiting time is increasing. Iranian protocol, a controlled transplant program supported by the government for living unrelated donors, was ...
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The use of stem cell-based protocols in transplantation has rapidly achieved many long-sought goals, including the induction of donor-specific tolerance and as an effective immunomodulatory therapy against acute cellular rejection and graft-versus-host disease. Recent advances in the fields of transplant immunology and regenerative medicine have significantly improved outcomes after solid organ...
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Recipient parenchymal lymphatic cells are crucial for direct and indirect pathways of allorecognition. We proposed that alemtuzumab, being infused several weeks pretransplant could eradicate peripheral lymphatic cells and promote donor-specific tolerance. We present here a single center, retrospective review of 101 consecutive living-donor kidney transplantations to pediatric patients aged from...
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ژورنال
عنوان ژورنال: American Journal of Transplantation
سال: 2018
ISSN: 1600-6135,1600-6143
DOI: 10.1111/ajt.14903